Your use of this information means that you agree to the Terms of Use. Learn how we develop our content. Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated. Uses L-phenylalanine LPA serves as a building block for the various proteins that are produced in the body.
What Are Star Ratings? This supplement has been used in connection with the following health conditions: Used for Why 2 Stars. In one study, depressed people given L-phenylalanine experienced results comparable to those produced by an antidepressant.
Several studies suggest that a synthetic version of phenylalanine called D-phenylalaline, may reduce pain by decreasing the enzyme that breaks down endorphins. D-phenylalanine DPA decreases pain by blocking the enzymes that break down the body's natural painkillers. Clinical studies suggest DPA may inhibit some types of chronic pain.
In one trial, D-phenylalanine DPA supplementation improved motor control and tremors in people with Parkinson's disease. L-phenylalanine, in conjunction with ultraviolet light exposure, may improve repigmentation of skin. In double-blind research, alcoholics treated with L-tyrosine combined with DLPA D,L-phenylalanine , L-glutamine, prescription L-tryptophan, plus a multivitamin had reduced withdrawal symptoms and decreased stress.
In double-blind research, alcoholics treated with DLPA D,L-phenylalanine combined with L-tyrosine, L-glutamine, prescription L-tryptophan, plus a multivitamin had reduced withdrawal symptoms and decreased stress. Supplementing with D-phenylalanine DPA has been shown to reduce chronic pain due to osteoarthritis.
DPA inhibits the enzyme that breaks down some of the body's natural painkillers. D-phenylalanine has been used with mixed results to treat chronic pain, including pain caused by rheumatoid arthritis.
Possible Deficiencies People whose diets are very low in protein may develop a deficiency of LPA, although this is believed to be very uncommon. Interactions with Medicines As of the last update, we found no reported interactions between this supplement and medicines. It is possible that unknown interactions exist. If you take medication, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist. The Drug-Nutrient Interactions table may not include every possible interaction.
Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers' package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a supplement with your doctor or pharmacist.
Related Information. References 1. Previous Section: References Top of the page. All rights reserved. There are several issues with using neurotransmitters themselves as supplements.
First, the neurotransmitters would have to make it through the digestive tract and into the brain. Not only is the digestive tract a harsh environment, the blood-brain barrier functions to only allow certain substances into and out of the brain. While some smaller molecules can readily cross this barrier and enter the central nervous system, larger molecules and neurotransmitters may not readily make this transit.
Supplementing with tyrosine, however, does not appear to produce the clinical outcomes of DLPA supplementation. For people who do not suffer from PKU, DL-phenylalanine supplementation may be a healthy option for treatment of mood, cognitive, behavioral, and motor problems.
Depression is one of the most commonly studied mental disorders and the target of many natural and pharmaceutical therapies. Pharmaceutical antidepressants are extremely helpful for many patients.
However, these medications, if misused or overprescribed, can result in negative side effects. Some of the most common side effects associated with SSRI selective serotonin reuptake-inhibitor use are decreased libido and apathy. Some researchers have even hypothesized that overeating and obesity may be due to inadequate dietary phenylalanine intake. The effects of acute dopamine precursor depletion on the cognitive control functions of performance monitoring and conflict processing: an event-related potential ERP study.
PLoS one, 10 10 , e Biosynthesis of Catecholamines. Patent Application No. Because of it raising serotonin levels which promote the production of melatonin it also helps with sleep. L-Glutamine- L-Glutamine is the most abundant free amino acid found in muscles of the body.
Because it can readily pass the blood —brain barrier, it is known as brain fuel. It produces GABA in the brain that is needed for brain function.
It also enhances antioxidant protection. It reduces sugar cravings and the desire for alcohol. It can produce a sense of stability and groundedness and promote healthy blood sugar balance.
It also is helpful in healing the gut. Gaba or Gamma-Aminobutyric Acid — is an amino acid that acts as a neurotransmitter in the central nervous system. It is essential for brain metabolism, aiding in proper brain function. Gaba decreases nerve activity and prevents nerve cells from over-firing.
It prevents anxiety and stress related messages from reaching the motor centers of the brain by occupying their receptor sites. This calms the body. Taurine —Is a conditional essential amino acids which means that in times of stress the body may not be able to manufacture enough of this amino acid.
It is a calming amino acid which is a key component of bile, is needed for the digestion of fats, and the metabolism of fat soluble vitamins A D E and K. It is vital for the proper utilization of sodium, potassium, calcium and magnesium. Taurine also enhances the effect of insulin helping the body to manage blood sugar more effectively.
This is beneficial for the Alcoholic who because of use has been unable to metabolize fats and fat soluble vitamins and therefore is depleted in this way. Animal research shows that brain levels of these substances decline with stress, and that giving animals tyrosine supplements reverses this decline and improves various tests of performance in stressed animals.
In a controlled study, a protein drink containing 10 grams per day of tyrosine was more effective than a carbohydrate drink for improving mental performance scores in a group of cadets taking a stressful six-day combat training course. A double-blind trial in humans found that one-time administration of mg of tyrosine per 2.
Single administrations of tyrosine to mg per 2. The amino acid L-tyrosine can be converted into norepinephrine, a neurotransmitter that affects mood. Women taking oral contraceptives have lower levels of tyrosine, and some researchers think this might be related to depression caused by birth control pills. L-tyrosine metabolism may also be abnormal in other depressed people and preliminary research suggests supplementation might help.
Several doctors recommend a week trial of L-tyrosine supplementation for people who are depressed. Published research has used a very high amount— mg per 2. It is not known whether such high amounts are necessary to produce an antidepressant effect. Kenneth Blum and researchers at the University of Texas have examined neurotransmitter deficiencies in alcoholics. Neurotransmitters are the chemicals the body makes to allow nerve cells to pass messages of pain , touch, thought, etc. Amino acids are the precursors of these neurotransmitters.
In double-blind research, a group of alcoholics were treated with 1. This nutritional supplement regimen led to a significant reduction in withdrawal symptoms and decreased stress in alcoholics compared to the effects of placebo. L-tyrosine is the direct precursor to L-dopa.
Theoretically, supplementing L-tyrosine could be an alternative to L-dopa therapy; however, L-tyrosine should not be taken with L-dopa as it may interfere with the transport of L-dopa to the brain. One small preliminary trial demonstrated that some people with Parkinson's disease who supplemented with L-tyrosine 45 mg per pound of body weight for three years had better clinical results and fewer side effects than did patients using L-dopa.
Until these findings are confirmed, L-tyrosine should not be used as a replacement for, or in addition to, L-dopa. Most people should not supplement with L-tyrosine. Some human research with people suffering from a variety of conditions used mg per 2.
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